A Catalytic Multicomponent Approach for the Stereoselective Synthesis of Cis-4,5-Disubstituted Pyrrolidinones and Tetrahydro-3H-pyrrolo[3,2-c]quinolines.
Abstract:In a three-component reaction, furancarbaldehydes, anilines, and the monocyclopropanated pyrrole can be assembled highly stereoselectively to give cis-4,5-disubstituted pyrrolidinones (see scheme; Boc = tert-butoxycarbonyl). The products are lead structures for pharmaceutically important compounds.