1. Shrutisagar Dattatraya Haveli, Sudipta Roy, Srinivasan Chandrasekaran. Synthesis of Unnatural C-2 Amino Acid Nucleosides Using NIS-Mediated Ring Opening of 1, 2-Cyclopropane Carboxylated Sugar Derivatives.
Abstract:We have developed a general and efficient method for the stereoselective construction of pyrimidine-based pyranosyl C-2 amino acid nucleosides using NIS-mediated ring opening of 1,2- cyclopropanated sugar derivatives. This methodology has been successfully extended to the synthesis of furanosyl nucleosides, which have potential applications in the development of novel, nontoxic antifungal therapeutics.